Purpose

Objectives
To build a PETRA database consisting of individual patient data (including PET scans) of the major international clinical studies on the value of i-PET in lymphomas
To determine the optimal timing of i-PET during first-line therapy with R-CHOP of DLBCL
To determine which i-PET response criteria perform best in predicting end-of-therapy response rate and progression-free survival at 2 years follow-up in patients with DLBCL
To assess whether and how chemo-immunotherapy affects the performance of i-PET
To assess whether and how type of NHL affects the performance of interim [18]FDG-PET
To determine the cost-effectiveness of i-PET in DLBCL
Publications
Zijlstra, J. M., Burggraaff, C. N., Kersten, M. J., Barrington, S. F., & EHA Scientific Working Group on Lymphoma (2016). FDG-PET as a biomarker for early response in diffuse large B-cell lymphoma as well as in Hodgkin lymphoma? Ready for implementation in clinical practice?. Haematologica, 101(11), 1279–1283. https://doi.org/10.3324/haematol.2016.142752
Burggraaff, C. N., de Jong, A., Hoekstra, O. S., Hoetjes, N. J., Nievelstein, R., Jansma, E. P., Heymans, M. W., de Vet, H., & Zijlstra, J. M. (2019). Predictive value of interim positron emission tomography in diffuse large B-cell lymphoma: a systematic review and meta-analysis. European journal of nuclear medicine and molecular imaging, 46(1), 65–79. https://doi.org/10.1007/s00259-018-4103-3
Zwezerijnen, G., Eertink, J. J., Burggraaff, C. N., Wiegers, S. E., Shaban, E., Pieplenbosch, S., Oprea-Lager, D. E., Lugtenburg, P. J., Hoekstra, O. S., de Vet, H., Zijlstra, J. M., & Boellaard, R. (2021). Interobserver Agreement on Automated Metabolic Tumor Volume Measurements of Deauville Score 4 and 5 Lesions at Interim 18F-FDG PET in Diffuse Large B-Cell Lymphoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(11), 1531–1536. https://doi.org/10.2967/jnumed.120.258673
Burggraaff, C. N., Cornelisse, A. C., Hoekstra, O. S., Lugtenburg, P. J., De Keizer, B., Arens, A., Celik, F., Huijbregts, J. E., De Vet, H., Zijlstra, J. M., & HOVON Imaging Working Group (2018). Interobserver Agreement of Interim and End-of-Treatment 18F-FDG PET/CT in Diffuse Large B-Cell Lymphoma: Impact on Clinical Practice and Trials. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(12), 1831–1836. https://doi.org/10.2967/jnumed.118.210807
Eertink, J. J., Burggraaff, C. N., Heymans, M. W., Dührsen, U., Hüttmann, A., Schmitz, C., Müller, S., Lugtenburg, P. J., Barrington, S. F., Mikhaeel, N. G., Carr, R., Czibor, S., Györke, T., Ceriani, L., Zucca, E., Hutchings, M., Kostakoglu, L., Loft, A., Fanti, S., Wiegers, S. E., … de Vet, H. (2021). Optimal timing and criteria of interim PET in DLBCL: a comparative study of 1692 patients. Blood advances, 5(9), 2375–2384. https://doi.org/10.1182/bloodadvances.2021004467
Barrington, S. F., Eertink, J. J., de Vet, H., George Mikhaeel, N., Hoekstra, O. S., & Zijlstra, J. M. (2021). Not Yet Time to Abandon the Deauville Criteria in Diffuse Large B-Cell Lymphoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(11), 1655–1656. https://doi.org/10.2967/jnumed.121.262317
Burggraaff, C. N., Eertink, J. J., Lugtenburg, P. J., Hoekstra, O. S., Arens, A., de Keizer, B., Heymans, M. W., van der Holt, B., Wiegers, S. E., Pieplenbosch, S., Boellaard, R., de Vet, H., & Zijlstra, J. M. (2021). 18F-FDG PET improves baseline clinical predictors of response in diffuse large B-cell lymphoma: The HOVON-84 study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, jnumed.121.262205. Advance online publication. https://doi.org/10.2967/jnumed.121.262205
Eertink, J. J., Arens, A., Huijbregts, J. E., Celik, F., de Keizer, B., Stroobants, S., de Jong, D., Wiegers, S. E., Zwezerijnen, G., Burggraaff, C. N., Boellaard, R., de Vet, H., Hoekstra, O. S., Lugtenburg, P. J., Chamuleau, M., Zijlstra, J. M., & HOVON imaging workgroup (2021). Aberrant patterns of PET response during treatment for DLBCL patients with MYC gene rearrangements. European journal of nuclear medicine and molecular imaging, 10.1007/s00259-021-05498-7. Advance online publication. https://doi.org/10.1007/s00259-021-05498-7